Acquired immunogenicity of autologous cells in cell culture – implications for cell therapy

June 15, 2011

The recent buzz in the iPS cell field made me look at the problem of acquired immunogenicity by isogenic (autologous) cells in prolonged ex vivo culture. The immunogenicity of iPS cells didn’t come as a surprise to me, because I was aware of some data indicating possible acquired immunogenicity of autologous cells. Frankly, in the [...]

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The role of hematopoietic stem cell transplantation in treatment of radiation exposure

May 25, 2011

Intro: Because of recent Japanese Fukushima nuclear disaster, I was trying to investigate the significance of stem cell transplantation in treatment of severe radiation exposure. I’ve proposed to select rescue workers based on data about available HLA-matched sample in Japanese bone marrow registry. But, probably, the best solution could be the harvest of autologous hematopoietic [...]

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Tracking of clinical trials and cases in cell therapy and regenerative medicine

May 9, 2011

I’ve started a new project – Cell Therapy Trials. The project dedicated to tracking of clinical trials and cases in cell therapy. The main goal is collecting all possible information about clinical trials and cases, which shared online for public. At the moment this is very amateur and i’m doing it mainly for myself. But [...]

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An update for cord blood clinical trials

April 28, 2011

I’ve wrote this mini-review for Canadian family cord blood bank “Insception” two months ago. This is online version of review. Please note, that this material is copyrighted by Insception and my CC license doesn’t apply. ************** Since the introduction to clinical practice in 1988, cord blood (CB) transplantation has gone all the way from experimental [...]

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Mechanisms of therapeutic action in cell therapy – a paradigm shift

April 21, 2011

Intro When we apply cell therapy in the clinic we want to injected cells to fix tissue damage/ disease. It is important to know the mechanisms by which cells will be able to repair/ regenerate a tissue. Historically, the first and the most important mechanism that was proposed, is a cell replacement. It was very [...]

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The hallmarks of adult stem cells

March 30, 2011

Our knowledge about stem cells is evolving. I’d like to summarize the current understanding of adult stem cell properties as a whole. Recent research has shown there are some common features for all somatic stem cells residing in different organs. Some of these features overlap with embryonic stem cells, some are distinct. 1. Self-renewal The [...]

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International Symposium – Current Issues of Cell-Based Technologies

March 16, 2011

Today I’d like to promote a conference. The organizers of the Symposium are very good friends of mine. So, I pleased to support this small international conference. ************************************ Human Stem Cells Institute (Moscow) R.M.Gorbacheva Institute of Children’s Hematology and Transplantology I.P.Pavlov State Medical University (Saint Petersburg) IV Annual International Symposium: «Current Issues of Cell-Based Technologies» [...]

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Revised: Cell cycle kinetics of hematopoietic stem cells

March 10, 2011

Intro: Cell cycle kinetics of the hematopoitic stem cell (HSC) population is very important in normal physiology of hematopoietic system and in pathological conditions. The current understanding of cell cycle kinetics of adult stem cell populations is based on two models: (1) The vast majority of adult stem cells in the population (up to 90-95% [...]

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The role of cancer stem cells in malignant mesothelioma

February 24, 2011

I’m continue to experiment with guest posts. If you would like to write something in focus of my blog, let me know. ************************ this is a guest post by Eric Stevenson* Mesothelioma is a rare and aggressive cancer that affects the lining of the internal organs, most commonly in the chest (pleural mesothelium) or abdomen [...]

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Studying hematopoietic stem cells in adult spleen

February 13, 2011

I’ve written about the role of spleen in adult hematopoiesis before. Now, I’d like to share my journal club presentation of the paper: Functional characterization of hematopoietic stem cells in the spleen. This is the only study, which addresses the question of functionality hematopoietic stem cells in adult spleen. This is online version of the [...]

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