Stem cell misconceptions – therapy

September 8, 2011

I’d like to start a new series entitled “Stem cell misconceptions”. I’ll highlight some important, currently misleading opinions and misconceptions in the stem cell research and cell therapy field. Please note, that this series will solely reflect my humble opinion (except possible guest posts). Also, this series will reflect a current opinion, which could change […]

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“Stem cell” label as a marketing tool

July 28, 2011

Honestly, I don’t like to talk much about stem cell politics, ethics, regulations and big business. I’d love to focus on analysis of scientific work or clinical studies. But sometimes, some things piss me off so badly, so, I can’t keep my mouth shut. Commercialization or branding of name “stem cell” is one of these […]

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Cell competition and selection as a driver of malignant progression

July 9, 2011

Intro Guys, we’re experiencing the era of tumor environment appreciation in cancer research. Cancer progression is not cell autonomous! It depends so much on the environmental context. But to complete a picture, please take into account a competition between cancer and normal cells for their environment. Cell competition as a biological phenomenon has been studied […]

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Trends in cancer stem cells – Interaction between stem cells and their niche in malignancy

June 29, 2011

Specific anatomical microenvironment or niche is a hallmark of adult somatic stem cell. Based on the analogy, it was proposed that cancer stem cells (CSC) also have their niches: In either scenario, the CSC niches and the CSC entities are linked like an amniotic sack and a fetus; one cannot exist without the other. But […]

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Acquired immunogenicity of autologous cells in cell culture – implications for cell therapy

June 15, 2011

The recent buzz in the iPS cell field made me look at the problem of acquired immunogenicity by isogenic (autologous) cells in prolonged ex vivo culture. The immunogenicity of iPS cells didn’t come as a surprise to me, because I was aware of some data indicating possible acquired immunogenicity of autologous cells. Frankly, in the […]

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The role of hematopoietic stem cell transplantation in treatment of radiation exposure

May 25, 2011

Intro: Because of recent Japanese Fukushima nuclear disaster, I was trying to investigate the significance of stem cell transplantation in treatment of severe radiation exposure. I’ve proposed to select rescue workers based on data about available HLA-matched sample in Japanese bone marrow registry. But, probably, the best solution could be the harvest of autologous hematopoietic […]

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Tracking of clinical trials and cases in cell therapy and regenerative medicine

May 9, 2011

I’ve started a new project – Cell Therapy Trials. The project dedicated to tracking of clinical trials and cases in cell therapy. The main goal is collecting all possible information about clinical trials and cases, which shared online for public. At the moment this is very amateur and i’m doing it mainly for myself. But […]

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An update for cord blood clinical trials

April 28, 2011

I’ve wrote this mini-review for Canadian family cord blood bank “Insception” two months ago. This is online version of review. Please note, that this material is copyrighted by Insception and my CC license doesn’t apply. ************** Since the introduction to clinical practice in 1988, cord blood (CB) transplantation has gone all the way from experimental […]

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Mechanisms of therapeutic action in cell therapy – a paradigm shift

April 21, 2011

Intro When we apply cell therapy in the clinic we want to injected cells to fix tissue damage/ disease. It is important to know the mechanisms by which cells will be able to repair/ regenerate a tissue. Historically, the first and the most important mechanism that was proposed, is a cell replacement. It was very […]

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The hallmarks of adult stem cells

March 30, 2011

Our knowledge about stem cells is evolving. I’d like to summarize the current understanding of adult stem cell properties as a whole. Recent research has shown there are some common features for all somatic stem cells residing in different organs. Some of these features overlap with embryonic stem cells, some are distinct. 1. Self-renewal The […]

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