Comments for Hematopoiesis

Comment on The definition of stem cell therapy by Raphael G

Raphael G — Sat, 19 May 2012 19:11:35 +0000

Thanks for your imput, I fully agree with your new definitions. So far I felt lonely in the “hype world of stem cells”, trying to convince others to use the term “stem cells” in therapy only if they differentiate to produce the target tissue to replace definitely failing tissues (which in the vast majority of cases never happen). So I am not the only child claiming that “the emperor is naked”.

Comment on Stem Cell Autopsy: The first teratoma case unfolded by Alexey Bersenev

Alexey Bersenev — Sat, 19 May 2012 14:00:56 +0000

Jen,
I believe that it was only brain tissue. In the book, Folkerth discuss the possibility of graft contamination by surrounding tissues in case of inaccurate dissection. But she also can’t explain the presence of cartilage. So, it seem like the version of teratoma is more convincing for her.
I think the possibility to cross-contaminate brain tissue by multipotent progenitors from surrounding tissues is exist, but less likely.

Comment on Stem Cell Autopsy: The first teratoma case unfolded by Jen Moody

Jen Moody — Sat, 19 May 2012 12:30:36 +0000

btw, very interesting post:)

Comment on Stem Cell Autopsy: The first teratoma case unfolded by Jen Moody

Jen Moody — Sat, 19 May 2012 12:30:12 +0000

I don’t think it necessarily means the cells retained pluripotency for that long. You could infer pluripotency if you knew the starting population was uniform. If the dissection was not precise, it could have included all kinds of multipotent progenitors.

Comment on Analysis of autopsy material after allogeneic mesencymal stromal cell infusions by Maria Cabreira

Maria Cabreira — Mon, 14 May 2012 16:25:58 +0000

Thanks for the posting! We were intrigued by our findings of MSC in the lymph nodes. This study supports ours.

Comment on Analysis of autopsy material after allogeneic mesencymal stromal cell infusions by Glenn McGee

Glenn McGee — Sat, 12 May 2012 18:04:33 +0000

The tie to engraftment is interesting…I saw a major review article about to come out that analyzes the dozens of studies of the “homing” of MSCs and deals with this “hit and run” phenomenon with an emphasis on how the cell function is called for and regulated. I am blanking on the name of the lab at Penn that just did a great study on MSC homing as well.

Comment on Analysis of autopsy material after allogeneic mesencymal stromal cell infusions by Paul Knoepfler

Paul Knoepfler — Sat, 12 May 2012 14:30:08 +0000

This is a great piece, Alexey.
The data here provide some important answers. I hope other similar studies will be conducted to build on this. I wonder if patients were to survive and live decades, could those few remaining allogeneic cells cause health problems or would ultimately essentially all be “cleared”? I wonder if we could figure out the molecular details of the “hit and run” could a small molecule therapy substitute for the cells themselves? The no tumors finding is very encouraging because even though patients who live may not present clinically with a tumor you never know if they have one, but autopsy analysis is definitive.
Paul

Comment on How to train the immune system to kill cancer stem cells? by chris

chris — Sat, 12 May 2012 04:02:15 +0000

How about sorting out the CSC in a tumour and fusing those cells with an allogeneic HSC. What if that hybrid cell can then produce all the immune cells found in the blood.
What would happen if even just the white blood cells from such a source are injected into the patient??

Comment on Analysis of autopsy material after allogeneic mesencymal stromal cell infusions by deev roman

deev roman — Fri, 11 May 2012 03:07:28 +0000

In bone tissue engraftment????

Comment on Cell therapy clinical trials in 2011 by Aline M. Betancourt, PhD

Aline M. Betancourt, PhD — Thu, 05 Apr 2012 18:59:12 +0000

Alexey–great timing I will include some of your cool pics in a review chapter I am writing for Springer. I will send you the info. when it gets published. Thanks for ALL you do for cell-based therapies! Best wishes, ali