Today, I’d like to introduce a guest post by Frances Verter. Dr. Verter is a Founder and a Director of Parent’s Guide to Cord Blood Foundation.
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This is a guest post by Frances Verter
This table is an effort to capture a snapshot of all the current clinical trials that are using stem cells from blood or tissues harvested at birth.
The primary research source for this table was searches of ClinicalTrials.gov between Dec. 2011 and Mar. 2012. I have also relied on Lee Buckler’s posts to his Cell Therapy Blog.
Emerging Therapies with Perinatal Tissues and Stem Cells
| Indication | Occurance in USA | Cell Source | Donor Type | Stage of Use | Trial or Product |
| Cartilage Repair |
9.6% men > age 60 and 18% women > age 60 |
cord blood |
allogeneic | approved by KFDA | Cartistem Medipost Co. Ltd. |
| Wound dressing |
Acute burn 450,000 hospital visits per year | amnion
amnion |
allogeneic
allogeneic allogeneic |
FDA
FDA Beike trial: 2 |
BioDfactor |
| Eye surface repair | corneal abrasion incidence 1.57% per year | amion | allogeneic | FDA | Prokera |
| Cerebral Palsy | 2 per 1000 full term births | cord blood | autologous
autologous autologous allogeneic |
Duke: 2
Georgia: 2 Monterrey:1 SunKwang:2 |
NCT01147653 |
| Hypoxic Ischemic Encephalopathy | 2 per 1000 full term births | cord blood | autologous | clinical trial: phase 1 |
NCT00593242 |
| Traumatic Brain Injury | 435,000 per year ages 0-14, #1 cause child death |
cord blood | autologous | clinical trial: phase 1 |
NCT01251003 |
| Spinal Cord Injury | 12,000 per year | cord tissue | allogeneic | clinical trial: phase 2 |
NCT01393977 |
| Hearing loss, sensorineural | 1 per 1000 births | cord blood | autologous | clinical trial: phase 1 |
NCT01343394 |
| Hypoplastic Left Heart Syndrome | 0.2 per 1000 births | cord blood | autologous | clinical trial: phase 1 |
NCT01445041 |
| Type 1 Diabetes | 1.7 per 1000 ages birth-19 | cord blood | autologous
autologous allogeneic |
Munchen: 1
U. FL: 2 China: 2 |
NCT00989547 |
| Ischemic Stroke | 8.1% adults over age 65 had stroke, #3 cause of adult death | cord blood
cord tissue cord blood & placental cells |
allogeneic allogeneic allogeneic |
China: 1 Gen Hosp:2 Celgene: 2 |
NCT01438593 NCT01389453 NCT01310114 |
| Critical Limb Ischemia | 2.5 per 1000 people, >80% of them diabetics | cord blood | allogeneic | Clinical trial: phase 1 |
NCT01019681 |
| Rheumatoid Arthritis | 6 per 1000 people | placental cells | allogeneic | Celgene trial: phase 2 |
NCT01261403 |
| Crohn’s Disease | 1 per 10,000 people ages 10-19 | placental cells | allogeneic | Celgene trial: phase 2 |
NCT01155362 |
Table copyright Frances Verter, PhD 2012
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