Tracking of clinical trials and cases in cell therapy and regenerative medicine

by Alexey Bersenev on May 9, 2011 · 1 comment

in clinical trials and cases

Post to Twitter

I’ve started a new project – Cell Therapy Trials. The project dedicated to tracking of clinical trials and cases in cell therapy. The main goal is collecting all possible information about clinical trials and cases, which shared online for public. At the moment this is very amateur and i’m doing it mainly for myself. But I’d be happy to know if you have any interest to participate and analyze data from this collection.

As a starting platform I choose Twitter, because I simply share a title with a link. Also because this platform is gaining a lot of attention, very popular and well indexed by search engines. In future I’d like to catalog all info in folders by cell type, disease or geographical location of the trial.

The difference and advantage of this tracking resource in comparison with existent databases is the following:

1. @CellTrials is collecting information from different registries and aggregators, including:
US ClinicalTrials.gov
Clinical Trials Registry – India (CTRI)
EU Clinical Trials Register
International Clinical Trials Registry Platform (aggregator) by WHO
Current Controlled Trials

for example, this trial registered in CTRI but not in ClinicalTrials.gov and not indexed by WHO or other aggregators:

BM-derived adult stem cells in the treatment of patients with complete spinal cord injury – Ph II (India) http://bit.ly/iVVSufless than a minute ago via web Favorite Retweet Reply

or this trial – you can track in english by WHO aggregator, but not by any other registries:

Fabrication of 3D scaffold-free stem cell plug for cartilage regeneration by human adipose derived stem cell (Japan) http://bit.ly/lWY3ziless than a minute ago via web Favorite Retweet Reply

2. If your query in database “stem cell” or “cell therapy”, you will get something like 50-95% (depends on registry) of hematopoietic stem cell (HSC) transplantation trials in hematology in your result. Let’s call it “HSC for homologous use”. @CellTrials is very selective filter and cut off “HSC for homologous use” trials. The only exclusion is HSC/ progenitors expansion trials. Nevertheless, all other cell types, used in hematology before or after HSC transplantation or alone are tracked.

3. Unlike information in registries, @CellTrials track reports of results or outcome, published in peer-reviewed literature. Interestingly, some published trial reports are not registered in public databases.

For example, follow-up of this trial, wasn’t indexed by registry, but press-release was tracked by @CellTrials:

ImmunoCellular Therapeutics presented long-term follow-up Ph I trial of dendritic cell therapy in glioblastoma http://bit.ly/lTMaxYless than a minute ago via web Favorite Retweet Reply

4. @CellTrials tracks the trials, sponsored by companies with link to official press-releases or business news aggregators. I’ve noticed, that some trials launched by companies aren’t indexed by registries.

5. @CellTrials tracks published or reported clinical cases and observational studies. We can learn a lot of useful information from these cases.

for example:

Umbilical cord- versus bone marrow-derived mesenchymal stem cells for treatment of acute GVHD – 4 cases study (Taiwan) http://bit.ly/fdfYD9less than a minute ago via web Favorite Retweet Reply


Benign abdominal tumor developed in a child with adenosine deaminase deficiency corrected by cellular gene therapy http://1.usa.gov/kRNrlPless than a minute ago via web Favorite Retweet Reply

6. Finally, in the future there is a possibility to analyze these data. For example, how many trials were launched in 2011? What were indications and location of these trials? It will be interesting to make a catalog of bookmarks sorted by cell type, phase of trial, indication and so on.

Please let me know if you’re interested in potential collaboration. Please let me know if you know good web tools, which could be very useful for making a public searchable catalog and tags cloud.

Please follow:
@CellTrials

Related posts:

  1. to be a hero
  2. Roadblocks for cell therapy clinical trials
  3. Safety of mismatched cord blood transplantation in regenerative medicine
  4. Cell therapy clinical trials 2009 – part IV
  5. Cell therapy clinical trials 2009 – part II

{ 1 comment… read it below or add one }

Discount Medical Supplies June 10, 2011 at 12:27 pm

Good to know about tracking clinical cases cell therapy regenerative medicine..
Thanks for sharing with us..

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