Comments on: Some thoughts about clinical-grade cord blood hematopoietic stem cell expansion http://hematopoiesis.info/2010/02/01/some-thoughts-about-clinical-grade-cord-blood-hematopoietic-stem-cell-expansion/ Blood Stem Cell & Cell Therapy Trends Sat, 19 May 2012 19:11:35 +0000 hourly 1 http://wordpress.org/?v=3.3.2 By: Alex http://hematopoiesis.info/2010/02/01/some-thoughts-about-clinical-grade-cord-blood-hematopoietic-stem-cell-expansion/#comment-12515 Alex Thu, 08 Jul 2010 14:46:13 +0000 http://hematopoiesis.info/?p=1249#comment-12515 @Dr M.Chandrashekhar - Studies still ongoing to assess the difference in neutrophil recovery in 1 unit versus 2 units of CB transplant. I think data so far is different between centers. One oh the last studies didn't detect difference - http://bloodjournal.hematologylibrary.org/cgi/content/full/114/19/4293 I like that they mixed expanded with fresh samples, because it's much safer and we can get more answers about efficiency of expansion. According Frances (see first comment) the cost for 2x CB transplant also doubled, because you purchase 2 samples. So it is very expensive procedure. @Dr M.Chandrashekhar -
Studies still ongoing to assess the difference in neutrophil recovery in 1 unit versus 2 units of CB transplant. I think data so far is different between centers. One oh the last studies didn’t detect difference -
http://bloodjournal.hematologylibrary.org/cgi/content/full/114/19/4293
I like that they mixed expanded with fresh samples, because it’s much safer and we can get more answers about efficiency of expansion.

According Frances (see first comment) the cost for 2x CB transplant also doubled, because you purchase 2 samples. So it is very expensive procedure.

]]> By: Dr M.Chandrashekhar http://hematopoiesis.info/2010/02/01/some-thoughts-about-clinical-grade-cord-blood-hematopoietic-stem-cell-expansion/#comment-12514 Dr M.Chandrashekhar Thu, 08 Jul 2010 08:59:52 +0000 http://hematopoiesis.info/?p=1249#comment-12514 Some mistakes in my earlier post. Interesting discussions. I always thought that in Double Unit CB both were expanded. Did not know that only one is expanded. Does Double Cord Blood transplant help in better & faster engraftment of neutrophils & platelets ? I also would like to know the cost factor. Some mistakes in my earlier post.
Interesting discussions. I always thought that in Double Unit CB both were expanded. Did not know that only one is expanded.

Does Double Cord Blood transplant help in better & faster engraftment of neutrophils & platelets ? I also would like to know the cost factor.

]]> By: Dr M.Chandrashekhar http://hematopoiesis.info/2010/02/01/some-thoughts-about-clinical-grade-cord-blood-hematopoietic-stem-cell-expansion/#comment-12513 Dr M.Chandrashekhar Thu, 08 Jul 2010 08:55:57 +0000 http://hematopoiesis.info/?p=1249#comment-12513 Interesting discussions. I always that in Double Unit CB both were expanded. Did not know that only one is expanded. Does Double Cord Blood transplant help in better & faster engraftment of neutrophils & platelets ? Interesting discussions. I always that in Double Unit CB both were expanded. Did not know that only one is expanded.

Does Double Cord Blood transplant help in better & faster engraftment of neutrophils & platelets ?

]]> By: Alex http://hematopoiesis.info/2010/02/01/some-thoughts-about-clinical-grade-cord-blood-hematopoietic-stem-cell-expansion/#comment-12298 Alex Wed, 03 Feb 2010 16:00:37 +0000 http://hematopoiesis.info/?p=1249#comment-12298 Thank you Frances for information. It was not clear for me why Replicell trials discontinued. Why is it so expensive - 30k for hospitals - to purchase CB sample from NMDP? Thank you Frances for information. It was not clear for me why Replicell trials discontinued. Why is it so expensive – 30k for hospitals – to purchase CB sample from NMDP?

]]> By: Frances Verter, PhD http://hematopoiesis.info/2010/02/01/some-thoughts-about-clinical-grade-cord-blood-hematopoietic-stem-cell-expansion/#comment-12294 Frances Verter, PhD Tue, 02 Feb 2010 23:02:40 +0000 http://hematopoiesis.info/?p=1249#comment-12294 There is a competition between expanded cord blood transplants versus double cord blood transplants for clinical use in adults. It is not only a question of what is medically effective but also what is cost effective. The first trail of expanded cord blood in adult leukemia patients, published in 2000, used the Replicell device from the company Aastrom Biosciences. If I remember correctly, the Replicell device cost about $100K. That was its undoing, and Astrom abandoned work on it years ago. I would like to hear more comparison of the financial cost of current expansion methods, in terms of both lab equipment and trained employee labor. Double cord transplants are very expensive, given that the cost to obtain each cord blood unit is about $30K from the NMDP. If expanded cord blood is just as good medically, and costs less than $60K, then third party payers will favor it over the double cord treatment modality, which is currently very popular. There is a competition between expanded cord blood transplants versus double cord blood transplants for clinical use in adults. It is not only a question of what is medically effective but also what is cost effective.

The first trail of expanded cord blood in adult leukemia patients, published in 2000, used the Replicell device from the company Aastrom Biosciences. If I remember correctly, the Replicell device cost about $100K. That was its undoing, and Astrom abandoned work on it years ago.

I would like to hear more comparison of the financial cost of current expansion methods, in terms of both lab equipment and trained employee labor.

Double cord transplants are very expensive, given that the cost to obtain each cord blood unit is about $30K from the NMDP. If expanded cord blood is just as good medically, and costs less than $60K, then third party payers will favor it over the double cord treatment modality, which is currently very popular.

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