http://hematopoiesis.info/2009/12/27/cancer-stem-cell-niche-as-a-therapeutic-target/ Blood Stem Cell & Cell Therapy Trends Fri, 20 Jan 2012 01:41:14 +0000 hourly 1 http://wordpress.org/?v=3.3.1 http://hematopoiesis.info/2009/12/27/cancer-stem-cell-niche-as-a-therapeutic-target/#comment-12187 Joanna Mon, 28 Dec 2009 00:56:42 +0000 http://hematopoiesis.info/?p=1189#comment-12187 A little irrelevant, there's a recent article that discusses how HIF2 is a central axis common to many tumor types (http://www.pnas.org/content/106/50/21306.short?rss=1). Seems like drugs that target this TF will be particularly potent. HIF2 is of course differentially expressed from HIF1. I don't have a lot of knowledge about HIF1. Is HIF1 a common axis in blood disorders? If so, it's a better target than others for drug development. A little irrelevant, there’s a recent article that discusses how HIF2 is a central axis common to many tumor types (http://www.pnas.org/content/106/50/21306.short?rss=1). Seems like drugs that target this TF will be particularly potent. HIF2 is of course differentially expressed from HIF1. I don’t have a lot of knowledge about HIF1. Is HIF1 a common axis in blood disorders? If so, it’s a better target than others for drug development.

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