Nobody has yet tested which cells actually contribute to disease in patients.
Therapies must eliminate all cells with the potential to contribute to disease.
One of the best lectures that I’ve heard this year so far was Sean Morrison‘s talk at University of Pennsylvania. Research in his lab made me think for the first time about complexity of cancer stem cell concept. For me he is an example of how real basic science should be done.
His “cancer stem cells” talk was recently recorded in the Koch Institute Symposium, held on June 19, 2009 at MIT.
He is talking about some very new unpublished data at the end of the lecture. I’d like to bring your attention to one of the last slide, shows that high frequency of tumorigenic cells (serially transplantable) could be observed not only in highly immunocompromised mice (like NOG), but also in fully immunocompetent histocompatible.
Robert Weinberg – Cancer stem cells and malignant progression
Catriona Jamieson – The molecular evolution of leukemic stem cells
Irving Weissman – Stem Cells: Units in Regeneration, Cancer, and Natural Selection
Owen Witte – A Delicate Balance: Stem Cells, Cancer and the Immune Response