Comments on: Intra-bone cord blood transplantation – the new clinical route to enhance engraftment http://hematopoiesis.info/2008/09/19/intra-bone-cord-blood-transplantation-the-new-clinical-route-to-enhance-engraftment/ Blood Stem Cell & Cell Therapy Trends Fri, 20 Jan 2012 01:41:14 +0000 hourly 1 http://wordpress.org/?v=3.3.1 By: Alex http://hematopoiesis.info/2008/09/19/intra-bone-cord-blood-transplantation-the-new-clinical-route-to-enhance-engraftment/#comment-8962 Alex Sun, 21 Sep 2008 18:35:09 +0000 http://hematopoiesis.info/2008/09/19/intra-bone-cord-blood-transplantation-the-new-clinical-route-to-enhance-engraftment/#comment-8962 engraftment in both ways of delivery (iv or intra-bone) should be very high, because of body irradiation or myeloablative regimen of chemotherapy. The targeting difference is "time of engraftment" or how soon we can see donor's cells in bloodstream. So compare with iv route, intra-bone seem like give a little bit faster engraftment for neutrophils (23 days median) and platelets (36 days median). Even you can accept that you deliver HSC directly to the niche, you really don't know is this true or not, because you can't measure (visualize) it so far. Even so, a lot of donor's cells injected into the bone goes directly to the bloodstream and travel around the body because bone cavity is highly vascularized. engraftment in both ways of delivery (iv or intra-bone) should be very high, because of body irradiation or myeloablative regimen of chemotherapy. The targeting difference is “time of engraftment” or how soon we can see donor’s cells in bloodstream. So compare with iv route, intra-bone seem like give a little bit faster engraftment for neutrophils (23 days median) and platelets (36 days median).

Even you can accept that you deliver HSC directly to the niche, you really don’t know is this true or not, because you can’t measure (visualize) it so far. Even so, a lot of donor’s cells injected into the bone goes directly to the bloodstream and travel around the body because bone cavity is highly vascularized.

]]> By: JWS http://hematopoiesis.info/2008/09/19/intra-bone-cord-blood-transplantation-the-new-clinical-route-to-enhance-engraftment/#comment-8785 JWS Fri, 19 Sep 2008 18:13:54 +0000 http://hematopoiesis.info/2008/09/19/intra-bone-cord-blood-transplantation-the-new-clinical-route-to-enhance-engraftment/#comment-8785 Good diagram - didn't know where people actually inject. I was hoping something very high engraftment rate though - why is it still not even close to 100% success rate after cells are directly injected into niche? Good diagram – didn’t know where people actually inject. I was hoping something very high engraftment rate though – why is it still not even close to 100% success rate after cells are directly injected into niche?

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