http://hematopoiesis.info/2008/09/12/how-do-traveling-normal-and-malignant-cells-decide-where-to-stay-lessons-from-mammary-cells/ Blood Stem Cell & Cell Therapy Trends Mon, 14 May 2012 16:25:58 +0000 hourly 1 http://wordpress.org/?v=3.3.2 http://hematopoiesis.info/2008/09/12/how-do-traveling-normal-and-malignant-cells-decide-where-to-stay-lessons-from-mammary-cells/#comment-15402 stocperspho Thu, 16 Dec 2010 02:05:04 +0000 http://hematopoiesis.info/2008/09/12/how-do-traveling-normal-and-malignant-cells-decide-where-to-stay-lessons-from-mammary-cells/#comment-15402 "As early as 1889, Steven Paget proposed a theory of “seed” and “soil” for breast cancer and bone metastasis. Rohr and Hegglin physically observed breast metastasis cancer cells in bone marrow biopsies from clinically diagnosed metastatic cases. Then the concept of micro-metastasis was brought forward by indentification of single metastatic tumor cell in bone marrow from clinically non-metastatic breast cancer patients. Those traveling cancer cells are called Disseminated Tumor cells (DTC) and Circulating Tumor Cells (CTC). However, only 50% of patients with DTCs eventually developed clinically diagnosed metastatic cancer. The other astonishing fact about DTC and CTC is that some cell markers, may not necessarily be identical to their primary counterparts. Now we know DTC and CTC are bona-fide avant-garde of breast cancers and the next question is how to take advantage of them for diagnosis and treatment." How much is it true? “As early as 1889, Steven Paget proposed a theory of “seed” and “soil” for breast cancer and bone metastasis. Rohr and Hegglin physically observed breast metastasis cancer cells in bone marrow biopsies from clinically diagnosed metastatic cases. Then the concept of micro-metastasis was brought forward by indentification of single metastatic tumor cell in bone marrow from clinically non-metastatic breast cancer patients. Those traveling cancer cells are called Disseminated Tumor cells (DTC) and Circulating Tumor Cells (CTC). However, only 50% of patients with DTCs eventually developed clinically diagnosed metastatic cancer. The other astonishing fact about DTC and CTC is that some cell markers, may not necessarily be identical to their primary counterparts. Now we know DTC and CTC are bona-fide avant-garde of breast cancers and the next question is how to take advantage of them for diagnosis and treatment.”
How much is it true?

]]> http://hematopoiesis.info/2008/09/12/how-do-traveling-normal-and-malignant-cells-decide-where-to-stay-lessons-from-mammary-cells/#comment-10093 Cancer Research Blog Carnival #14 | Articles Plaza Sun, 05 Oct 2008 13:30:26 +0000 http://hematopoiesis.info/2008/09/12/how-do-traveling-normal-and-malignant-cells-decide-where-to-stay-lessons-from-mammary-cells/#comment-10093 [...] of glioblastoma, the most common primary brain tumour in adults. On Hematopoiesis, we learn how travelling normal and malignant cells decide where to stay and on get linked up to five great talks from the [...] [...] of glioblastoma, the most common primary brain tumour in adults. On Hematopoiesis, we learn how travelling normal and malignant cells decide where to stay and on get linked up to five great talks from the [...]

]]> http://hematopoiesis.info/2008/09/12/how-do-traveling-normal-and-malignant-cells-decide-where-to-stay-lessons-from-mammary-cells/#comment-10094 Cancer Research Blog Carnival #14 | Articles Plaza Sun, 05 Oct 2008 13:30:25 +0000 http://hematopoiesis.info/2008/09/12/how-do-traveling-normal-and-malignant-cells-decide-where-to-stay-lessons-from-mammary-cells/#comment-10094 [...] of glioblastoma, the most common primary brain tumour in adults. On Hematopoiesis, we learn how travelling normal and malignant cells decide where to stay and on get linked up to five great talks from the [...] [...] of glioblastoma, the most common primary brain tumour in adults. On Hematopoiesis, we learn how travelling normal and malignant cells decide where to stay and on get linked up to five great talks from the [...]

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