Comments on: Should hematopoietic scheme be revised? Dr. Jerimiah Bell interview

By: Lei

Lei — Tue, 05 Aug 2008 21:48:00 +0000

Cell reprogramming is always fascinating. Goodell’s Cell Stem Cell paper in 2007 showed distinct gene expression profile between HSC and different lineages, so-called lineage fingerprint. This group further demonstrated that ZFP105 and ETS2 can biase HSC to NK and MNC after BMT, respectively. While inducible stem cell research found OCT4 promoter cannot be demethylated at DNA level after induction thus hampers it to achieve its full expression since OCT4 is not supposed to reactivated after differentiation. It seems we’ll screw ourselves up before we can screw the cells up.

By: Alex

Alex — Sat, 21 Jun 2008 00:57:43 +0000

I’d agree with Dr. Bell that you can not revised current scheme without same kind of experiments with bone marrow. I just wondering why it is not been done yet.

By: JWS

JWS — Thu, 19 Jun 2008 16:28:52 +0000

Cool interview: old question + new techniques..

By: oracy

oracy — Wed, 18 Jun 2008 02:36:44 +0000

Very informative. Well done to both of you.