Comments on: Stem Cells, Quiescence and Cancer http://hematopoiesis.info/2008/06/05/stem-cells-quiescence-and-cancer/ Blood Stem Cell & Lineages Tue, 06 Jan 2009 07:16:08 +0000 http://wordpress.org/?v=2.3.1 By: Alex http://hematopoiesis.info/2008/06/05/stem-cells-quiescence-and-cancer/#comment-10887 Alex Wed, 17 Dec 2008 04:57:18 +0000 http://hematopoiesis.info/2008/06/05/stem-cells-quiescence-and-cancer/#comment-10887 Yes cancer stem cells (CSC) should be quiescent because they are "altered adult stem cells". That's why so hard to kill them, that's why they are almost undistinguished from normal adult stem cells. EMT is the phenomenon of transition from normal tissue stem or progenitor to CSC, so it's not CSC themself - it is a transition process. That's why it's proliferative. What is speculation? Yes cancer stem cells (CSC) should be quiescent because they are “altered adult stem cells”. That’s why so hard to kill them, that’s why they are almost undistinguished from normal adult stem cells.
EMT is the phenomenon of transition from normal tissue stem or progenitor to CSC, so it’s not CSC themself - it is a transition process. That’s why it’s proliferative. What is speculation?

]]> By: Reynald http://hematopoiesis.info/2008/06/05/stem-cells-quiescence-and-cancer/#comment-10886 Reynald Wed, 17 Dec 2008 00:58:39 +0000 http://hematopoiesis.info/2008/06/05/stem-cells-quiescence-and-cancer/#comment-10886 I think recent data when taken together would tend to counter the assertion that CSCs are quiescent. Based on the work by Mani in weinberg's lab and numerous observations it seems pretty clear that in the case of solid cancers, CSCs and the EMT are the same thing. In that case it has been shown that the EMT phenotype is in fact proliferative. Although this is simply informed speculation. I think recent data when taken together would tend to counter the assertion that CSCs are quiescent. Based on the work by Mani in weinberg’s lab and numerous observations it seems pretty clear that in the case of solid cancers, CSCs and the EMT are the same thing. In that case it has been shown that the EMT phenotype is in fact proliferative. Although this is simply informed speculation.

]]> By: Smith http://hematopoiesis.info/2008/06/05/stem-cells-quiescence-and-cancer/#comment-8332 Smith Mon, 15 Sep 2008 11:42:10 +0000 http://hematopoiesis.info/2008/06/05/stem-cells-quiescence-and-cancer/#comment-8332 This is a very informative post, i was searching in Google for bladder Cancer and came across this post. My niece is suffering from bladder Cancer, information mention in this article will greatly help me in offering her some advice. This is a very informative post, i was searching in Google for bladder Cancer and came across this post. My niece is suffering from bladder Cancer, information mention in this article will greatly help me in offering her some advice.

]]> By: cancer cure http://hematopoiesis.info/2008/06/05/stem-cells-quiescence-and-cancer/#comment-5119 cancer cure Thu, 14 Aug 2008 03:48:09 +0000 http://hematopoiesis.info/2008/06/05/stem-cells-quiescence-and-cancer/#comment-5119 <strong>cancer cure...</strong> if you'd like to ask some one else how much they like this post i think the answer is goingto be.. very much, an original blog... cancer cure…

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