Comments on: Leukemic death http://hematopoiesis.info/2008/05/31/leukemic-death/ Blood Stem Cell & Lineages Tue, 06 Jan 2009 06:11:56 +0000 http://wordpress.org/?v=2.3.1 By: Alex http://hematopoiesis.info/2008/05/31/leukemic-death/#comment-766 Alex Tue, 17 Jun 2008 06:19:44 +0000 http://hematopoiesis.info/2008/05/31/leukemic-death/#comment-766 I don't know what is exact mechanism. Bone marrow cells were around that long because they came from original donor (1st bone marrow transplant) - genetically modified mouse with abnormal hematopoiesis and HSC self-renewal. But these mice don't develop leukemia-like disease spontaneously - they live happy life. So when I transplanted BM cells from them I promote enhanced self-renewal that leads to leukemia-like fatal disease development. It will take some time from me to understand mechanisms and repeat experiments with controls. I don’t know what is exact mechanism. Bone marrow cells were around that long because they came from original donor (1st bone marrow transplant) - genetically modified mouse with abnormal hematopoiesis and HSC self-renewal. But these mice don’t develop leukemia-like disease spontaneously - they live happy life. So when I transplanted BM cells from them I promote enhanced self-renewal that leads to leukemia-like fatal disease development. It will take some time from me to understand mechanisms and repeat experiments with controls.

]]> By: jonrowley http://hematopoiesis.info/2008/05/31/leukemic-death/#comment-754 jonrowley Sun, 15 Jun 2008 01:19:05 +0000 http://hematopoiesis.info/2008/05/31/leukemic-death/#comment-754 so, can you explain to a lay-biomedical engineer what the mechanism is? you say 4th serial Tx, so is it possible the cells have been around too long? btw: cool picture so, can you explain to a lay-biomedical engineer what the mechanism is? you say 4th serial Tx, so is it possible the cells have been around too long?

btw: cool picture

]]> By: cc http://hematopoiesis.info/2008/05/31/leukemic-death/#comment-721 cc Wed, 04 Jun 2008 22:30:57 +0000 http://hematopoiesis.info/2008/05/31/leukemic-death/#comment-721 WOW! WOW!

]]> By: Alex http://hematopoiesis.info/2008/05/31/leukemic-death/#comment-719 Alex Wed, 04 Jun 2008 04:35:31 +0000 http://hematopoiesis.info/2008/05/31/leukemic-death/#comment-719 thanks! I was really really impressed, other animal from the same group had spleen = 1.72g vs 0.1g in normal mice. It was biggest spleen that i ever seen! thanks! I was really really impressed,
other animal from the same group had spleen = 1.72g vs 0.1g in normal mice. It was biggest spleen that i ever seen!

]]> By: JWS http://hematopoiesis.info/2008/05/31/leukemic-death/#comment-718 JWS Tue, 03 Jun 2008 20:15:11 +0000 http://hematopoiesis.info/2008/05/31/leukemic-death/#comment-718 awesome!! awesome!!

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