Steven Rosenberg has pioneered first clinical protocols of the adoptive cell transfer for treatment of advanced stages of cancer.

In 1988 he published results of the first adoptive cell transfer (tumor-infiltrating lymphocytes = TIL) protocol used in 20 patients with metastatic melanoma.

So what has changed over the past 20 years?
You go to read and find out!

Adoptive cell therapy (ACT) using autologous tumour-infiltrating lymphocytes has emerged as the most effective treatment for patients with metastatic melanoma and can mediate objective cancer regression in approximately 50% of patients.

Nat Rev Cancer 8, 299-308 (April 2008) | doi:10.1038/nrc2355

you can download review here