Cancer Research Blog Carnival #9

by Alexey Bersenev on May 2, 2008 · 1 comment

in cancer

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Cancer Research Blog Carnival (CRBC) is on!
Welcome to the May 2, 2008 (#9) edition!

I would like to start with the news from one of the top cancer research conferences – American Association for Cancer Research (AACR), which was held on April 12-16 in San Diego, California.

Kamel at BayBlab presents AACR Mini-Carnival about some reports from conference.

Charls Daney at Science and Reason reviews about TOR signaling and ovarian cancer, including report from AACR.
Researchers from Yale University identified ovarian cancer stem cells for the first time. The same team in the preclinical study shows that the drug NV-128, developed by Novogen, induces the death of ovarian cancer cells by halting activation of mTOR pathway.

Read more about advances in cancer stem cells, reported at AACR, on ScienceDaily The Role Of Cancer-initiating Cells In Diagnosis And Treatment

Identification and targeting of cancer stem cells is a very hot topic today. I analyzed recent publication about identification leukemia-initiating cells for human B-cell acute lymphocytic leukemia.

Also I was really impressed by the recent mini-review from Nature Biotechnology about the companies that have started competing for development of new drugs, selectively targeting cancer stem cells.

Very interesting Ian’s opinion, based on a literature review, about human endogenous retroviruses (HERVs) and link to immunity and cancer you can find at Mystery Rays from Outer Space.
I learn that human genome is littered by remaining retrovirus. Because HERVs are defective, they don’t stimulate immune system and normally do not express. But some pathological conditions can cause HERV activation and it has become a target for autoimmunity, cytotoxic T-cell immune response and anti-cancer immunity. Also it seems that HERV could be a common antigen for some tumors and potentially a new target for therapy.

More about viruses! Tim Sampson at Blogging for Bacteriophages presents analysis of the review about Myxoma virus and oncolytic virotherapy. Honestly, I even didn’t know about this kind of therapy – using live viruses to kill malignant cells in situ. So I learned a lot. Highly recommended to read!

Let’s get close to the clinic. Stories about the link between viruses and cancer continue. David Loeb at Doctor David’s Blog is continuing discussion about the recent discovery, which shows that human papillomavirus (HPV) causes oral cancer. You will find out why it’s important.

Ok, This is it for today’s Carnival. It was a full of research news and these will lead us to future diagnostics and impact on cancer patient treatment!
Let’s understand and conquer cancer together and always stay tuned for the latest hot news with Cancer Research Blog Carnival.

The next carnival is Friday June 6.
If you would like to contribute and host the next issue of CRBC, please submit your post here.

Thanks to Steppen Wolf for the 8th edition and to Kamel at BayBlab for help.

Photo: Ovarian cancer cells, SEM
Coloured scanning electron micrograph (SEM) of ovarian cancer cells. These large rounded cells have uneven surfaces with many cytoplasmic projections, which may enable them to be motile. Typically, cancer cells are large and they divide rapidly in a chaotic manner. Clumps of these cells (tumours) may form and invade and destroy surrounding tissues. Magnification: x1200 at 6x7cm size.
(credit: Steve Gschmeissner, SciencePhotoLibrary)
Ovarian cancer September 5, 2008 at 9:11 am

This post is very useful for me because my friends mother is suffering from the ovarian cancer. This would help me to tell some important caution about ovarian cancer.
Thanks for your time to post this article.

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