Comments on: Twins help to keep track of leukemia-initiating cells http://hematopoiesis.info/2008/01/24/twins-help-to-keep-track-of-leukemia-initiating-cells/ Blood Stem Cell & Cell Therapy Trends Fri, 20 Jan 2012 01:41:14 +0000 hourly 1 http://wordpress.org/?v=3.3.1 By: omron blood monitor http://hematopoiesis.info/2008/01/24/twins-help-to-keep-track-of-leukemia-initiating-cells/#comment-12116 omron blood monitor Wed, 11 Nov 2009 16:06:10 +0000 http://hematopoiesis.info/2008/01/24/twins-help-to-keep-track-of-leukemia-initiating-cells/#comment-12116 Blood cancer are required to make many decisions about their care. They must decide where the care will take place and choose the physician who will take charge of care. Blood cancer are not common, around 1 in 25 of the population will develop a blood cancer and so one would expect to sometimes see more than one case in a family purely by chance. Blood cancer are required to make many decisions about their care. They must decide where the care will take place and choose the physician who will take charge of care. Blood cancer are not common, around 1 in 25 of the population will develop a blood cancer and so one would expect to sometimes see more than one case in a family purely by chance.

]]> By: yogi setyo http://hematopoiesis.info/2008/01/24/twins-help-to-keep-track-of-leukemia-initiating-cells/#comment-11097 yogi setyo Thu, 26 Feb 2009 16:25:44 +0000 http://hematopoiesis.info/2008/01/24/twins-help-to-keep-track-of-leukemia-initiating-cells/#comment-11097 This is a very informative and useful article for me.This post is very useful for me. This would help me to tell some important caution about cancer. Thank you very much This is a very informative and useful article for me.This post is very useful for me. This would help me to tell some important caution about cancer.
Thank you very much

]]> By: Alex http://hematopoiesis.info/2008/01/24/twins-help-to-keep-track-of-leukemia-initiating-cells/#comment-7 Alex Sat, 26 Jan 2008 01:44:35 +0000 http://hematopoiesis.info/2008/01/24/twins-help-to-keep-track-of-leukemia-initiating-cells/#comment-7 I read it again and realize that appearance of this population CD34+/CD38–/CD19+ caused by first-hit mutation will try to contact authors to clarify I read it again and realize that appearance of this population CD34+/CD38–/CD19+ caused by first-hit mutation
will try to contact authors to clarify

]]> By: Alex http://hematopoiesis.info/2008/01/24/twins-help-to-keep-track-of-leukemia-initiating-cells/#comment-6 Alex Fri, 25 Jan 2008 05:19:30 +0000 http://hematopoiesis.info/2008/01/24/twins-help-to-keep-track-of-leukemia-initiating-cells/#comment-6 Other thing what I didn't get completely from the paper - why authors claim TEL-AML1 first-hit mutation? Why not others? For example TEL-JAK2 fusion or Bcr-Abl? Other thing what I didn’t get completely from the paper – why authors claim TEL-AML1 first-hit mutation?
Why not others? For example TEL-JAK2 fusion or Bcr-Abl?

]]> By: Alex http://hematopoiesis.info/2008/01/24/twins-help-to-keep-track-of-leukemia-initiating-cells/#comment-5 Alex Fri, 25 Jan 2008 05:17:00 +0000 http://hematopoiesis.info/2008/01/24/twins-help-to-keep-track-of-leukemia-initiating-cells/#comment-5 It's seem like authors proposed 3 types of LSCs: 1. CD34+/CD38-/CD19+ pre-LSCs for ALL (this population is absent in the bone marrow of healthy people) 2. CD34+/CD38-/CD19+/TEL-AML1+ some cells acquired first-hit mutation - LSCs persist in bone marrow without clinical manifestation (was in healthy twin) 3. CD34+/CD38-/CD19+/TEL-AML1+/other mutations+ LSCs acquired multiply mutations - trigger for disease development (was in leukemic twin). So answer is CD34+/CD38–/CD19+ will not cause disease by them self. How they are appear? I don't know. Maybe other - not so strong mutation of normal HSCs (CD34+/CD38-). It’s seem like authors proposed 3 types of LSCs:
1. CD34+/CD38-/CD19+ pre-LSCs for ALL (this population is absent in the bone marrow of healthy people)
2. CD34+/CD38-/CD19+/TEL-AML1+ some cells acquired first-hit mutation – LSCs persist in bone marrow without clinical manifestation (was in healthy twin)
3. CD34+/CD38-/CD19+/TEL-AML1+/other mutations+
LSCs acquired multiply mutations – trigger for disease
development (was in leukemic twin).

So answer is CD34+/CD38–/CD19+ will not cause disease by them self.
How they are appear? I don’t know. Maybe other – not so strong mutation of normal HSCs (CD34+/CD38-).

]]> By: yoshiko http://hematopoiesis.info/2008/01/24/twins-help-to-keep-track-of-leukemia-initiating-cells/#comment-4 yoshiko Fri, 25 Jan 2008 05:03:54 +0000 http://hematopoiesis.info/2008/01/24/twins-help-to-keep-track-of-leukemia-initiating-cells/#comment-4 I read the paper again after you told me the value of the paper. I still wonder whaat will cause the CD34+/CD38–/CD19+ cells? Is it also because of some mutations of genes? How do scientists think about this point? I read the paper again after you told me the value of the paper.
I still wonder whaat will cause the CD34+/CD38–/CD19+ cells?
Is it also because of some mutations of genes?
How do scientists think about this point?

]]>