Comments on: Twins help to keep track of leukemia-initiating cells

By: Alex

Alex — Sat, 26 Jan 2008 01:44:35 +0000

I read it again and realize that appearance of this population CD34+/CD38–/CD19+ caused by first-hit mutation
will try to contact authors to clarify

By: Alex

Alex — Fri, 25 Jan 2008 05:19:30 +0000

Other thing what I didn’t get completely from the paper - why authors claim TEL-AML1 first-hit mutation?
Why not others? For example TEL-JAK2 fusion or Bcr-Abl?

By: Alex

Alex — Fri, 25 Jan 2008 05:17:00 +0000

It’s seem like authors proposed 3 types of LSCs:
1. CD34+/CD38-/CD19+ pre-LSCs for ALL (this population is absent in the bone marrow of healthy people)
2. CD34+/CD38-/CD19+/TEL-AML1+ some cells acquired first-hit mutation - LSCs persist in bone marrow without clinical manifestation (was in healthy twin)
3. CD34+/CD38-/CD19+/TEL-AML1+/other mutations+
LSCs acquired multiply mutations - trigger for disease
development (was in leukemic twin).

So answer is CD34+/CD38–/CD19+ will not cause disease by them self.
How they are appear? I don’t know. Maybe other - not so strong mutation of normal HSCs (CD34+/CD38-).

By: yoshiko

yoshiko — Fri, 25 Jan 2008 05:03:54 +0000

I read the paper again after you told me the value of the paper.
I still wonder whaat will cause the CD34+/CD38–/CD19+ cells?
Is it also because of some mutations of genes?
How do scientists think about this point?