Lab profile: Dr. Connie J. Eaves

by Alexey Bersenev on December 18, 2007 · 0 comments

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I’d like to introduce new category – “Labs”.
Here we will post information about laboratories, groups and centers which are working in the field of hematopoiesis, stem cells and leukemia research.

I hope that a compilation of such information will be very helpful for young people, many of whom are looking for career growth in the dynamic field of stem cell research.

I’d like to start from a remarkable person, who was the pioneer of many hematopoietic stem cell assays.

Connie J. Eaves

She is director and co-founder of the Terry Fox Laboratory at The BC Cancer Research Centre (Vancouver, British Columbia, Canada)

Her lab is focused on normal hematopoiesis and stem cell biology, leukemogenesis and cancer stem cells.
Dr. Connie J. Eaves is one of the major developers of stem cell assays. Many of them became the “gold standard” in experimental hematology and stem cell research, such as the competitive repopulation assay.

Last publications list:

Long-Term Propagation of Distinct Hematopoietic Differentiation Programs In Vivo
Cell Stem Cell 2007; 1: 218-229

Near-maximal expansions of hematopoietic stem cells in culture using NUP98-HOX fusions
Exp Hematol. 2007 May;35(5):817-30

Improved purification of hematopoietic stem cells based on their elevated aldehyde dehydrogenase activity.
Haematologica. 2007 Sep;92(9):1165-72 (open access)

Instability of BCR-ABL gene in primary and cultured chronic myeloid leukemia stem cells.
J Natl Cancer Inst. 2007 May 2;99(9):680-93. (open access)

Chronic myeloid leukemia stem cells possess multiple unique features of resistance to BCR-ABL targeted therapies.
Leukemia. 2007 May;21(5):926-35

High-resolution video monitoring of hematopoietic stem cells cultured in single-cell arrays identifies new features of self-renewal.
Proc Natl Acad Sci U S A. 2006 May 23;103(21):8185-90 (open access)

Identification of a new intrinsically timed developmental checkpoint that reprograms key hematopoietic stem cell properties.
Proc Natl Acad Sci U S A. 2007 Apr 3;104(14):5878-82 (open access)

Hematopoietic stem cells proliferate until after birth and show a reversible phase-specific engraftment defect.
J Clin Invest. 2006 Oct;116(10):2808-16 (open access)

PubMed record

Connie Eaves Lab
Terry Fox Laboratory

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